About the IMPACT Consortium

Mission

• IMPACT accelerates discovery in pediatric cellular therapy by harmonizing immune monitoring, microbiota profiling, and clinical outcome data across six premier international institutions. Through unified assays and shared analytical pipelines, we build robust, reproducible multi-omics datasets that illuminate mechanisms of immune reconstitution, predict complications such as graft-versus-host disease (GVHD) and relapse, and inform targeted therapeutic strategies.

Vision

• A universal standard for immune and microbiota monitoring in pediatric HCT and CAR-T
• A shared data foundation to power biomarker discovery
• Predictive models integrating immune subsets, microbiome state, genetics, and clinical outcomes
• Improved survival and reduced treatment-related complications
• A platform for future interventional trials and risk-adapted therapy

What Makes IMPACT Unique

• Harmonized standard operating procedures (SOPs) across all participating sites
• Shared large spectral flow cytometry panels
• Matched Olink proteomics platforms
• Longitudinal multi-omics integration: immune, microbiome, and genetic data
• Cross-center data governance and integrated analytical frameworks