Shared experimental standards
Participating centers use harmonized standard operating procedures and aligned immune-monitoring workflows to support cross-center comparison.
About IMPACT
Building a shared foundation for pediatric cellular therapy discovery
The IMPACT Consortium brings together pediatric transplant and cellular therapy centers to harmonize immune monitoring, microbiome profiling, and clinical outcome data across institutions.
By aligning assays, sample processing, data structures, and analytical pipelines, IMPACT creates multi-center datasets that can reveal how immune recovery shapes complications such as graft-versus-host disease, relapse, infection, and long-term treatment response.
Immune
monitoring
monitoring
Microbiome
profiling
profiling
Clinical
outcomes
outcomes
IMPACT
Our mission
IMPACT accelerates discovery in pediatric HCT and CAR-T by transforming center-specific measurements into harmonized, reproducible, multi-omics datasets that can support biomarker discovery, predictive modeling, and future risk-adapted therapeutic strategies.
Standardize
Align immune monitoring, microbiome profiling, and sample handling across participating centers.
Integrate
Connect longitudinal immune, microbiome, proteomic, genetic, and clinical outcome data.
Translate
Use shared datasets to identify immune recovery patterns linked to complications and response.
What makes IMPACT different
A consortium built for harmonized discovery
Matched multi-omics platforms
IMPACT integrates spectral flow cytometry, Olink proteomics, microbiome profiling, and clinical data within a common translational framework.
Pediatric cellular therapy focus
The consortium is designed around pediatric HCT and CAR-T, where immune recovery, toxicity, relapse, and long-term outcomes require coordinated multi-center study.